Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.
Identifieur interne : 001142 ( Main/Exploration ); précédent : 001141; suivant : 001143Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.
Auteurs : Paola Nicoletti [États-Unis] ; Guruprasad P. Aithal [Royaume-Uni] ; Einar S. Bjornsson [Islande] ; Raul J. Andrade [Espagne] ; Ashley Sawle [États-Unis] ; Marco Arrese [Chili] ; Huiman X. Barnhart [États-Unis] ; Emmanuelle Bondon-Guitton [France] ; Paul H. Hayashi [États-Unis] ; Fernando Bessone [Argentine] ; Alfonso Carvajal [Espagne] ; Ingolf Cascorbi [Allemagne] ; Elizabeth T. Cirulli [États-Unis] ; Naga Chalasani [États-Unis] ; Anita Conforti [Italie] ; Sally A. Coulthard [Royaume-Uni] ; Mark J. Daly [États-Unis] ; Christopher P. Day [Royaume-Uni] ; John F. Dillon [Royaume-Uni] ; Robert J. Fontana [États-Unis] ; Jane I. Grove [Royaume-Uni] ; P R Hallberg [Suède] ; Nelia Hernández [Uruguay] ; Luisa Ibá Ez [Espagne] ; Gerd A. Kullak-Ublick [Suisse] ; Tarja Laitinen [Finlande] ; Dominique Larrey [France] ; M Isabel Lucena [Espagne] ; Anke H. Maitland-Van Der Zee [Pays-Bas] ; Jennifer H. Martin [Australie] ; Mariam Molokhia [Royaume-Uni] ; Munir Pirmohamed [Royaume-Uni] ; Elizabeth E. Powell [Australie] ; Shengying Qin [République populaire de Chine] ; Jose Serrano [États-Unis] ; Camilla Stephens [Espagne] ; Andrew Stolz [États-Unis] ; Mia Wadelius [Suède] ; Paul B. Watkins [États-Unis] ; Aris Floratos [États-Unis] ; Yufeng Shen [États-Unis] ; Matthew R. Nelson [États-Unis] ; Thomas J. Urban [États-Unis] ; Ann K. Daly [Royaume-Uni]Source :
- Gastroenterology [ 1528-0012 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Allèles, Antiagrégants plaquettaires (effets indésirables), Antidépresseurs (effets indésirables), Antifongiques (effets indésirables), Antigènes HLA-A (génétique), Chromosomes humains de la paire 2 (génétique), Femelle, Fénofibrate (effets indésirables), Gènes MHC de classe I (génétique), Humains, Hypolipémiants (effets indésirables), Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (effets indésirables), Lésions hépatiques dues aux substances (génétique), Lésions hépatiques dues aux substances (étiologie), Mâle, Naphtalènes (effets indésirables), Odds ratio, Phénotype, Polymorphisme de nucléotide simple, Population d'origine européenne (génétique), Prédisposition génétique à une maladie, Sertraline (effets indésirables), Ticlopidine (effets indésirables), Étude d'association pangénomique.
- MESH :
- effets indésirables : Antiagrégants plaquettaires, Antidépresseurs, Antifongiques, Fénofibrate, Hypolipémiants, Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase, Naphtalènes, Sertraline, Ticlopidine.
- génétique : Antigènes HLA-A, Chromosomes humains de la paire 2, Gènes MHC de classe I, Lésions hépatiques dues aux substances, Population d'origine européenne.
- étiologie : Lésions hépatiques dues aux substances.
- Adulte d'âge moyen, Allèles, Femelle, Humains, Mâle, Odds ratio, Phénotype, Polymorphisme de nucléotide simple, Prédisposition génétique à une maladie, Étude d'association pangénomique.
English descriptors
- KwdEn :
- Alleles, Antidepressive Agents (adverse effects), Antifungal Agents (adverse effects), Chemical and Drug Induced Liver Injury (etiology), Chemical and Drug Induced Liver Injury (genetics), Chromosomes, Human, Pair 2 (genetics), European Continental Ancestry Group (genetics), Female, Fenofibrate (adverse effects), Genes, MHC Class I (genetics), Genetic Predisposition to Disease, Genome-Wide Association Study, HLA-A Antigens (genetics), Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects), Hypolipidemic Agents (adverse effects), Male, Middle Aged, Naphthalenes (adverse effects), Odds Ratio, Phenotype, Platelet Aggregation Inhibitors (adverse effects), Polymorphism, Single Nucleotide, Sertraline (adverse effects), Ticlopidine (adverse effects).
- MESH :
- chemical , adverse effects : Antidepressive Agents, Antifungal Agents, Fenofibrate, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypolipidemic Agents, Naphthalenes, Platelet Aggregation Inhibitors, Sertraline, Ticlopidine.
- etiology : Chemical and Drug Induced Liver Injury.
- genetics : Chemical and Drug Induced Liver Injury, Chromosomes, Human, Pair 2, European Continental Ancestry Group, Genes, MHC Class I, HLA-A Antigens.
- Alleles, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Odds Ratio, Phenotype, Polymorphism, Single Nucleotide.
Abstract
We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors.
DOI: 10.1053/j.gastro.2016.12.016
PubMed: 28043905
Affiliations:
- Allemagne, Argentine, Australie, Chili, Espagne, Finlande, France, Islande, Italie, Pays-Bas, Royaume-Uni, République populaire de Chine, Suisse, Suède, Uruguay, États-Unis
- Angleterre, Californie, Caroline du Nord, Catalogne, East Middle Sweden, Grand Londres, Indiana, Languedoc-Roussillon, Maryland, Massachusetts, Michigan, Midi-Pyrénées, Occitanie (région administrative), Pennsylvanie, Schleswig-Holstein, Svealand, Utrecht (province), État de New York
- Barcelone, Kiel, Londres, Montpellier, Toulouse, Uppsala, Utrecht
- Université d'Uppsala, Université d'Utrecht
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Le document en format XML
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Barnhart</name><affiliation wicri:level="2"><nlm:affiliation>Duke University, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Duke University, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Bondon Guitton, Emmanuelle" sort="Bondon Guitton, Emmanuelle" uniqKey="Bondon Guitton E" first="Emmanuelle" last="Bondon-Guitton">Emmanuelle Bondon-Guitton</name><affiliation wicri:level="3"><nlm:affiliation>Universite de Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Universite de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Hayashi, Paul H" sort="Hayashi, Paul H" uniqKey="Hayashi P" first="Paul H" last="Hayashi">Paul H. Hayashi</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Internal Medicine, University of North Carolina-Chapel Hill, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Bessone, Fernando" sort="Bessone, Fernando" uniqKey="Bessone F" first="Fernando" last="Bessone">Fernando Bessone</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Gastroenterología y Hepatología, Universidad Nacional de Rosario, Rosario, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Servicio de Gastroenterología y Hepatología, Universidad Nacional de Rosario, Rosario</wicri:regionArea><wicri:noRegion>Rosario</wicri:noRegion></affiliation></author><author><name sortKey="Carvajal, Alfonso" sort="Carvajal, Alfonso" uniqKey="Carvajal A" first="Alfonso" last="Carvajal">Alfonso Carvajal</name><affiliation wicri:level="1"><nlm:affiliation>Universidad de Valladolid, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Universidad de Valladolid, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Cascorbi, Ingolf" sort="Cascorbi, Ingolf" uniqKey="Cascorbi I" first="Ingolf" last="Cascorbi">Ingolf Cascorbi</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Cirulli, Elizabeth T" sort="Cirulli, Elizabeth T" uniqKey="Cirulli E" first="Elizabeth T" last="Cirulli">Elizabeth T. Cirulli</name><affiliation wicri:level="2"><nlm:affiliation>Duke University, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Duke University, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Chalasani, Naga" sort="Chalasani, Naga" uniqKey="Chalasani N" first="Naga" last="Chalasani">Naga Chalasani</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis</wicri:cityArea></affiliation></author><author><name sortKey="Conforti, Anita" sort="Conforti, Anita" uniqKey="Conforti A" first="Anita" last="Conforti">Anita Conforti</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital, Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University Hospital, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Coulthard, Sally A" sort="Coulthard, Sally A" uniqKey="Coulthard S" first="Sally A" last="Coulthard">Sally A. Coulthard</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle Upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Daly, Mark J" sort="Daly, Mark J" uniqKey="Daly M" first="Mark J" last="Daly">Mark J. Daly</name><affiliation wicri:level="2"><nlm:affiliation>Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Broad Institute of Harvard and Massachusetts Institute of Technology, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Day, Christopher P" sort="Day, Christopher P" uniqKey="Day C" first="Christopher P" last="Day">Christopher P. Day</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle Upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Dillon, John F" sort="Dillon, John F" uniqKey="Dillon J" first="John F" last="Dillon">John F. Dillon</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Institute, University of Dundee, Ninewells Hospital, Dundee, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Institute, University of Dundee, Ninewells Hospital, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Fontana, Robert J" sort="Fontana, Robert J" uniqKey="Fontana R" first="Robert J" last="Fontana">Robert J. Fontana</name><affiliation wicri:level="2"><nlm:affiliation>University of Michigan, Ann Arbor, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Grove, Jane I" sort="Grove, Jane I" uniqKey="Grove J" first="Jane I" last="Grove">Jane I. Grove</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health Research, Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospital, National Health Service Trust, and University of Nottingham, Nottingham, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research, Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospital, National Health Service Trust, and University of Nottingham, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Hallberg, P R" sort="Hallberg, P R" uniqKey="Hallberg P" first="P R" last="Hallberg">P R Hallberg</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Hernandez, Nelia" sort="Hernandez, Nelia" uniqKey="Hernandez N" first="Nelia" last="Hernández">Nelia Hernández</name><affiliation wicri:level="1"><nlm:affiliation>Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay.</nlm:affiliation><country xml:lang="fr">Uruguay</country><wicri:regionArea>Facultad de Medicina, Universidad de la Republica, Montevideo</wicri:regionArea><wicri:noRegion>Montevideo</wicri:noRegion></affiliation></author><author><name sortKey="Iba Ez, Luisa" sort="Iba Ez, Luisa" uniqKey="Iba Ez L" first="Luisa" last="Ibá Ez">Luisa Ibá Ez</name><affiliation wicri:level="3"><nlm:affiliation>Fundació Institut Català de Farmacologia, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundació Institut Català de Farmacologia, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Kullak Ublick, Gerd A" sort="Kullak Ublick, Gerd A" uniqKey="Kullak Ublick G" first="Gerd A" last="Kullak-Ublick">Gerd A. Kullak-Ublick</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Pharmacology and Toxicology, University Hospital and University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Clinical Pharmacology and Toxicology, University Hospital and University of Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Laitinen, Tarja" sort="Laitinen, Tarja" uniqKey="Laitinen T" first="Tarja" last="Laitinen">Tarja Laitinen</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Research Unit for Pulmonary Diseases, Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Clinical Research Unit for Pulmonary Diseases, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Larrey, Dominique" sort="Larrey, Dominique" uniqKey="Larrey D" first="Dominique" last="Larrey">Dominique Larrey</name><affiliation wicri:level="3"><nlm:affiliation>Liver Unit, Centre Hospitalier Universitaire, St Eloi Hospital, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Liver Unit, Centre Hospitalier Universitaire, St Eloi Hospital, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Lucena, M Isabel" sort="Lucena, M Isabel" uniqKey="Lucena M" first="M Isabel" last="Lucena">M Isabel Lucena</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Gestión Clínica Digestivo, Instituto de Investigación Biomédica de Málaga, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Gestión Clínica Digestivo, Instituto de Investigación Biomédica de Málaga, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Maitland Van Der Zee, Anke H" sort="Maitland Van Der Zee, Anke H" uniqKey="Maitland Van Der Zee A" first="Anke H" last="Maitland-Van Der Zee">Anke H. Maitland-Van Der Zee</name><affiliation wicri:level="4"><nlm:affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region><settlement type="city">Utrecht</settlement></placeName><orgName type="university">Université d'Utrecht</orgName></affiliation></author><author><name sortKey="Martin, Jennifer H" sort="Martin, Jennifer H" uniqKey="Martin J" first="Jennifer H" last="Martin">Jennifer H. Martin</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine and Public Health, University of Newcastle, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine and Public Health, University of Newcastle, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Molokhia, Mariam" sort="Molokhia, Mariam" uniqKey="Molokhia M" first="Mariam" last="Molokhia">Mariam Molokhia</name><affiliation wicri:level="3"><nlm:affiliation>Department of Primary Care and Public Health Sciences, King's College, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Primary Care and Public Health Sciences, King's College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pirmohamed, Munir" sort="Pirmohamed, Munir" uniqKey="Pirmohamed M" first="Munir" last="Pirmohamed">Munir Pirmohamed</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Powell, Elizabeth E" sort="Powell, Elizabeth E" uniqKey="Powell E" first="Elizabeth E" last="Powell">Elizabeth E. Powell</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Liver Disease Research, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Liver Disease Research, School of Medicine, The University of Queensland, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Qin, Shengying" sort="Qin, Shengying" uniqKey="Qin S" first="Shengying" last="Qin">Shengying Qin</name><affiliation wicri:level="1"><nlm:affiliation>Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Serrano, Jose" sort="Serrano, Jose" uniqKey="Serrano J" first="Jose" last="Serrano">Jose Serrano</name><affiliation wicri:level="2"><nlm:affiliation>National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Stephens, Camilla" sort="Stephens, Camilla" uniqKey="Stephens C" first="Camilla" last="Stephens">Camilla Stephens</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Gestión Clínica Digestivo, Instituto de Investigación Biomédica de Málaga, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Gestión Clínica Digestivo, Instituto de Investigación Biomédica de Málaga, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Stolz, Andrew" sort="Stolz, Andrew" uniqKey="Stolz A" first="Andrew" last="Stolz">Andrew Stolz</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Wadelius, Mia" sort="Wadelius, Mia" uniqKey="Wadelius M" first="Mia" last="Wadelius">Mia Wadelius</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Watkins, Paul B" sort="Watkins, Paul B" uniqKey="Watkins P" first="Paul B" last="Watkins">Paul B. Watkins</name><affiliation wicri:level="2"><nlm:affiliation>University of North Carolina Institute for Drug Safety Sciences, Eshelman School of Pharmacy, Chapel Hill, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>University of North Carolina Institute for Drug Safety Sciences, Eshelman School of Pharmacy, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Floratos, Aris" sort="Floratos, Aris" uniqKey="Floratos A" first="Aris" last="Floratos">Aris Floratos</name><affiliation wicri:level="2"><nlm:affiliation>Department of Systems Biology, Columbia University, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Systems Biology, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Shen, Yufeng" sort="Shen, Yufeng" uniqKey="Shen Y" first="Yufeng" last="Shen">Yufeng Shen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Systems Biology, Columbia University, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Systems Biology, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Nelson, Matthew R" sort="Nelson, Matthew R" uniqKey="Nelson M" first="Matthew R" last="Nelson">Matthew R. Nelson</name><affiliation wicri:level="2"><nlm:affiliation>Target Sciences, GlaxoSmithKlein, King of Prussia, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Target Sciences, GlaxoSmithKlein, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Urban, Thomas J" sort="Urban, Thomas J" uniqKey="Urban T" first="Thomas J" last="Urban">Thomas J. Urban</name><affiliation wicri:level="2"><nlm:affiliation>UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Daly, Ann K" sort="Daly, Ann K" uniqKey="Daly A" first="Ann K" last="Daly">Ann K. Daly</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom. Electronic address: a.k.daly@ncl.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle Upon Tyne</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28043905</idno><idno type="pmid">28043905</idno><idno type="doi">10.1053/j.gastro.2016.12.016</idno><idno type="wicri:Area/PubMed/Corpus">000E79</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E79</idno><idno type="wicri:Area/PubMed/Curation">000E76</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E76</idno><idno type="wicri:Area/PubMed/Checkpoint">000E76</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E76</idno><idno type="wicri:Area/Ncbi/Merge">004111</idno><idno type="wicri:Area/Ncbi/Curation">004111</idno><idno type="wicri:Area/Ncbi/Checkpoint">004111</idno><idno type="wicri:Area/Main/Merge">001137</idno><idno type="wicri:Area/Main/Curation">001142</idno><idno type="wicri:Area/Main/Exploration">001142</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.</title><author><name sortKey="Nicoletti, Paola" sort="Nicoletti, Paola" uniqKey="Nicoletti P" first="Paola" last="Nicoletti">Paola Nicoletti</name><affiliation wicri:level="2"><nlm:affiliation>Department of Systems Biology, Columbia University, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Systems Biology, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Aithal, Guruprasad P" sort="Aithal, Guruprasad P" uniqKey="Aithal G" first="Guruprasad P" last="Aithal">Guruprasad P. Aithal</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health Research, Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospital, National Health Service Trust, and University of Nottingham, Nottingham, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research, Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospital, National Health Service Trust, and University of Nottingham, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Bjornsson, Einar S" sort="Bjornsson, Einar S" uniqKey="Bjornsson E" first="Einar S" last="Bjornsson">Einar S. Bjornsson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Landspitali University Hospital, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Internal Medicine, Landspitali University Hospital, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Andrade, Raul J" sort="Andrade, Raul J" uniqKey="Andrade R" first="Raul J" last="Andrade">Raul J. Andrade</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Gestión Clínica Digestivo, Instituto de Investigación Biomédica de Málaga, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Gestión Clínica Digestivo, Instituto de Investigación Biomédica de Málaga, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Sawle, Ashley" sort="Sawle, Ashley" uniqKey="Sawle A" first="Ashley" last="Sawle">Ashley Sawle</name><affiliation wicri:level="2"><nlm:affiliation>Department of Systems Biology, Columbia University, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Systems Biology, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Arrese, Marco" sort="Arrese, Marco" uniqKey="Arrese M" first="Marco" last="Arrese">Marco Arrese</name><affiliation wicri:level="1"><nlm:affiliation>Departmento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Departmento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Barnhart, Huiman X" sort="Barnhart, Huiman X" uniqKey="Barnhart H" first="Huiman X" last="Barnhart">Huiman X. Barnhart</name><affiliation wicri:level="2"><nlm:affiliation>Duke University, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Duke University, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Bondon Guitton, Emmanuelle" sort="Bondon Guitton, Emmanuelle" uniqKey="Bondon Guitton E" first="Emmanuelle" last="Bondon-Guitton">Emmanuelle Bondon-Guitton</name><affiliation wicri:level="3"><nlm:affiliation>Universite de Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Universite de Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Hayashi, Paul H" sort="Hayashi, Paul H" uniqKey="Hayashi P" first="Paul H" last="Hayashi">Paul H. Hayashi</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Internal Medicine, University of North Carolina-Chapel Hill, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Bessone, Fernando" sort="Bessone, Fernando" uniqKey="Bessone F" first="Fernando" last="Bessone">Fernando Bessone</name><affiliation wicri:level="1"><nlm:affiliation>Servicio de Gastroenterología y Hepatología, Universidad Nacional de Rosario, Rosario, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Servicio de Gastroenterología y Hepatología, Universidad Nacional de Rosario, Rosario</wicri:regionArea><wicri:noRegion>Rosario</wicri:noRegion></affiliation></author><author><name sortKey="Carvajal, Alfonso" sort="Carvajal, Alfonso" uniqKey="Carvajal A" first="Alfonso" last="Carvajal">Alfonso Carvajal</name><affiliation wicri:level="1"><nlm:affiliation>Universidad de Valladolid, Valladolid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Universidad de Valladolid, Valladolid</wicri:regionArea><wicri:noRegion>Valladolid</wicri:noRegion></affiliation></author><author><name sortKey="Cascorbi, Ingolf" sort="Cascorbi, Ingolf" uniqKey="Cascorbi I" first="Ingolf" last="Cascorbi">Ingolf Cascorbi</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Cirulli, Elizabeth T" sort="Cirulli, Elizabeth T" uniqKey="Cirulli E" first="Elizabeth T" last="Cirulli">Elizabeth T. Cirulli</name><affiliation wicri:level="2"><nlm:affiliation>Duke University, Durham, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Duke University, Durham</wicri:cityArea></affiliation></author><author><name sortKey="Chalasani, Naga" sort="Chalasani, Naga" uniqKey="Chalasani N" first="Naga" last="Chalasani">Naga Chalasani</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis</wicri:cityArea></affiliation></author><author><name sortKey="Conforti, Anita" sort="Conforti, Anita" uniqKey="Conforti A" first="Anita" last="Conforti">Anita Conforti</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital, Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University Hospital, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Coulthard, Sally A" sort="Coulthard, Sally A" uniqKey="Coulthard S" first="Sally A" last="Coulthard">Sally A. Coulthard</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle Upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Daly, Mark J" sort="Daly, Mark J" uniqKey="Daly M" first="Mark J" last="Daly">Mark J. Daly</name><affiliation wicri:level="2"><nlm:affiliation>Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Broad Institute of Harvard and Massachusetts Institute of Technology, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Day, Christopher P" sort="Day, Christopher P" uniqKey="Day C" first="Christopher P" last="Day">Christopher P. Day</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle Upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Dillon, John F" sort="Dillon, John F" uniqKey="Dillon J" first="John F" last="Dillon">John F. Dillon</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Institute, University of Dundee, Ninewells Hospital, Dundee, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Institute, University of Dundee, Ninewells Hospital, Dundee</wicri:regionArea><wicri:noRegion>Dundee</wicri:noRegion></affiliation></author><author><name sortKey="Fontana, Robert J" sort="Fontana, Robert J" uniqKey="Fontana R" first="Robert J" last="Fontana">Robert J. Fontana</name><affiliation wicri:level="2"><nlm:affiliation>University of Michigan, Ann Arbor, Michigan.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>University of Michigan, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Grove, Jane I" sort="Grove, Jane I" uniqKey="Grove J" first="Jane I" last="Grove">Jane I. Grove</name><affiliation wicri:level="1"><nlm:affiliation>National Institute for Health Research, Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospital, National Health Service Trust, and University of Nottingham, Nottingham, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>National Institute for Health Research, Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospital, National Health Service Trust, and University of Nottingham, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Hallberg, P R" sort="Hallberg, P R" uniqKey="Hallberg P" first="P R" last="Hallberg">P R Hallberg</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Hernandez, Nelia" sort="Hernandez, Nelia" uniqKey="Hernandez N" first="Nelia" last="Hernández">Nelia Hernández</name><affiliation wicri:level="1"><nlm:affiliation>Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay.</nlm:affiliation><country xml:lang="fr">Uruguay</country><wicri:regionArea>Facultad de Medicina, Universidad de la Republica, Montevideo</wicri:regionArea><wicri:noRegion>Montevideo</wicri:noRegion></affiliation></author><author><name sortKey="Iba Ez, Luisa" sort="Iba Ez, Luisa" uniqKey="Iba Ez L" first="Luisa" last="Ibá Ez">Luisa Ibá Ez</name><affiliation wicri:level="3"><nlm:affiliation>Fundació Institut Català de Farmacologia, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundació Institut Català de Farmacologia, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Kullak Ublick, Gerd A" sort="Kullak Ublick, Gerd A" uniqKey="Kullak Ublick G" first="Gerd A" last="Kullak-Ublick">Gerd A. Kullak-Ublick</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Pharmacology and Toxicology, University Hospital and University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Clinical Pharmacology and Toxicology, University Hospital and University of Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Laitinen, Tarja" sort="Laitinen, Tarja" uniqKey="Laitinen T" first="Tarja" last="Laitinen">Tarja Laitinen</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Research Unit for Pulmonary Diseases, Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Clinical Research Unit for Pulmonary Diseases, Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Larrey, Dominique" sort="Larrey, Dominique" uniqKey="Larrey D" first="Dominique" last="Larrey">Dominique Larrey</name><affiliation wicri:level="3"><nlm:affiliation>Liver Unit, Centre Hospitalier Universitaire, St Eloi Hospital, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Liver Unit, Centre Hospitalier Universitaire, St Eloi Hospital, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Lucena, M Isabel" sort="Lucena, M Isabel" uniqKey="Lucena M" first="M Isabel" last="Lucena">M Isabel Lucena</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Gestión Clínica Digestivo, Instituto de Investigación Biomédica de Málaga, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Gestión Clínica Digestivo, Instituto de Investigación Biomédica de Málaga, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Maitland Van Der Zee, Anke H" sort="Maitland Van Der Zee, Anke H" uniqKey="Maitland Van Der Zee A" first="Anke H" last="Maitland-Van Der Zee">Anke H. Maitland-Van Der Zee</name><affiliation wicri:level="4"><nlm:affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region><settlement type="city">Utrecht</settlement></placeName><orgName type="university">Université d'Utrecht</orgName></affiliation></author><author><name sortKey="Martin, Jennifer H" sort="Martin, Jennifer H" uniqKey="Martin J" first="Jennifer H" last="Martin">Jennifer H. Martin</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine and Public Health, University of Newcastle, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine and Public Health, University of Newcastle, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Molokhia, Mariam" sort="Molokhia, Mariam" uniqKey="Molokhia M" first="Mariam" last="Molokhia">Mariam Molokhia</name><affiliation wicri:level="3"><nlm:affiliation>Department of Primary Care and Public Health Sciences, King's College, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Primary Care and Public Health Sciences, King's College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pirmohamed, Munir" sort="Pirmohamed, Munir" uniqKey="Pirmohamed M" first="Munir" last="Pirmohamed">Munir Pirmohamed</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool</wicri:regionArea><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Powell, Elizabeth E" sort="Powell, Elizabeth E" uniqKey="Powell E" first="Elizabeth E" last="Powell">Elizabeth E. Powell</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Liver Disease Research, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Liver Disease Research, School of Medicine, The University of Queensland, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Qin, Shengying" sort="Qin, Shengying" uniqKey="Qin S" first="Shengying" last="Qin">Shengying Qin</name><affiliation wicri:level="1"><nlm:affiliation>Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, Shanghai, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Serrano, Jose" sort="Serrano, Jose" uniqKey="Serrano J" first="Jose" last="Serrano">Jose Serrano</name><affiliation wicri:level="2"><nlm:affiliation>National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Stephens, Camilla" sort="Stephens, Camilla" uniqKey="Stephens C" first="Camilla" last="Stephens">Camilla Stephens</name><affiliation wicri:level="1"><nlm:affiliation>Unidad de Gestión Clínica Digestivo, Instituto de Investigación Biomédica de Málaga, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Málaga, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unidad de Gestión Clínica Digestivo, Instituto de Investigación Biomédica de Málaga, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Málaga</wicri:regionArea><wicri:noRegion>Málaga</wicri:noRegion></affiliation></author><author><name sortKey="Stolz, Andrew" sort="Stolz, Andrew" uniqKey="Stolz A" first="Andrew" last="Stolz">Andrew Stolz</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Wadelius, Mia" sort="Wadelius, Mia" uniqKey="Wadelius M" first="Mia" last="Wadelius">Mia Wadelius</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences and Science for Life Laboratory, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Watkins, Paul B" sort="Watkins, Paul B" uniqKey="Watkins P" first="Paul B" last="Watkins">Paul B. Watkins</name><affiliation wicri:level="2"><nlm:affiliation>University of North Carolina Institute for Drug Safety Sciences, Eshelman School of Pharmacy, Chapel Hill, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>University of North Carolina Institute for Drug Safety Sciences, Eshelman School of Pharmacy, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Floratos, Aris" sort="Floratos, Aris" uniqKey="Floratos A" first="Aris" last="Floratos">Aris Floratos</name><affiliation wicri:level="2"><nlm:affiliation>Department of Systems Biology, Columbia University, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Systems Biology, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Shen, Yufeng" sort="Shen, Yufeng" uniqKey="Shen Y" first="Yufeng" last="Shen">Yufeng Shen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Systems Biology, Columbia University, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Systems Biology, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Nelson, Matthew R" sort="Nelson, Matthew R" uniqKey="Nelson M" first="Matthew R" last="Nelson">Matthew R. Nelson</name><affiliation wicri:level="2"><nlm:affiliation>Target Sciences, GlaxoSmithKlein, King of Prussia, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Target Sciences, GlaxoSmithKlein, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Urban, Thomas J" sort="Urban, Thomas J" uniqKey="Urban T" first="Thomas J" last="Urban">Thomas J. Urban</name><affiliation wicri:level="2"><nlm:affiliation>UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Daly, Ann K" sort="Daly, Ann K" uniqKey="Daly A" first="Ann K" last="Daly">Ann K. Daly</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom. Electronic address: a.k.daly@ncl.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle Upon Tyne</wicri:noRegion></affiliation></author></analytic><series><title level="j">Gastroenterology</title><idno type="eISSN">1528-0012</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alleles</term><term>Antidepressive Agents (adverse effects)</term><term>Antifungal Agents (adverse effects)</term><term>Chemical and Drug Induced Liver Injury (etiology)</term><term>Chemical and Drug Induced Liver Injury (genetics)</term><term>Chromosomes, Human, Pair 2 (genetics)</term><term>European Continental Ancestry Group (genetics)</term><term>Female</term><term>Fenofibrate (adverse effects)</term><term>Genes, MHC Class I (genetics)</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>HLA-A Antigens (genetics)</term><term>Humans</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects)</term><term>Hypolipidemic Agents (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Naphthalenes (adverse effects)</term><term>Odds Ratio</term><term>Phenotype</term><term>Platelet Aggregation Inhibitors (adverse effects)</term><term>Polymorphism, Single Nucleotide</term><term>Sertraline (adverse effects)</term><term>Ticlopidine (adverse effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Allèles</term><term>Antiagrégants plaquettaires (effets indésirables)</term><term>Antidépresseurs (effets indésirables)</term><term>Antifongiques (effets indésirables)</term><term>Antigènes HLA-A (génétique)</term><term>Chromosomes humains de la paire 2 (génétique)</term><term>Femelle</term><term>Fénofibrate (effets indésirables)</term><term>Gènes MHC de classe I (génétique)</term><term>Humains</term><term>Hypolipémiants (effets indésirables)</term><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (effets indésirables)</term><term>Lésions hépatiques dues aux substances (génétique)</term><term>Lésions hépatiques dues aux substances (étiologie)</term><term>Mâle</term><term>Naphtalènes (effets indésirables)</term><term>Odds ratio</term><term>Phénotype</term><term>Polymorphisme de nucléotide simple</term><term>Population d'origine européenne (génétique)</term><term>Prédisposition génétique à une maladie</term><term>Sertraline (effets indésirables)</term><term>Ticlopidine (effets indésirables)</term><term>Étude d'association pangénomique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antidepressive Agents</term><term>Antifungal Agents</term><term>Fenofibrate</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term><term>Hypolipidemic Agents</term><term>Naphthalenes</term><term>Platelet Aggregation Inhibitors</term><term>Sertraline</term><term>Ticlopidine</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antiagrégants plaquettaires</term><term>Antidépresseurs</term><term>Antifongiques</term><term>Fénofibrate</term><term>Hypolipémiants</term><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term><term>Naphtalènes</term><term>Sertraline</term><term>Ticlopidine</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Chemical and Drug Induced Liver Injury</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chemical and Drug Induced Liver Injury</term><term>Chromosomes, Human, Pair 2</term><term>European Continental Ancestry Group</term><term>Genes, MHC Class I</term><term>HLA-A Antigens</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA-A</term><term>Chromosomes humains de la paire 2</term><term>Gènes MHC de classe I</term><term>Lésions hépatiques dues aux substances</term><term>Population d'origine européenne</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lésions hépatiques dues aux substances</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Phenotype</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Allèles</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Odds ratio</term><term>Phénotype</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Étude d'association pangénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed a genome-wide association study (GWAS) to identify genetic risk factors for drug-induced liver injury (DILI) from licensed drugs without previously reported genetic risk factors.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Argentine</li><li>Australie</li><li>Chili</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Islande</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Suisse</li><li>Suède</li><li>Uruguay</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Caroline du Nord</li><li>Catalogne</li><li>East Middle Sweden</li><li>Grand Londres</li><li>Indiana</li><li>Languedoc-Roussillon</li><li>Maryland</li><li>Massachusetts</li><li>Michigan</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Pennsylvanie</li><li>Schleswig-Holstein</li><li>Svealand</li><li>Utrecht (province)</li><li>État de New York</li></region><settlement><li>Barcelone</li><li>Kiel</li><li>Londres</li><li>Montpellier</li><li>Toulouse</li><li>Uppsala</li><li>Utrecht</li></settlement><orgName><li>Université d'Uppsala</li><li>Université d'Utrecht</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Nicoletti, Paola" sort="Nicoletti, Paola" uniqKey="Nicoletti P" first="Paola" last="Nicoletti">Paola Nicoletti</name></region><name sortKey="Barnhart, Huiman X" sort="Barnhart, Huiman X" uniqKey="Barnhart H" first="Huiman X" last="Barnhart">Huiman X. Barnhart</name><name sortKey="Chalasani, Naga" sort="Chalasani, Naga" uniqKey="Chalasani N" first="Naga" last="Chalasani">Naga Chalasani</name><name sortKey="Cirulli, Elizabeth T" sort="Cirulli, Elizabeth T" uniqKey="Cirulli E" first="Elizabeth T" last="Cirulli">Elizabeth T. Cirulli</name><name sortKey="Daly, Mark J" sort="Daly, Mark J" uniqKey="Daly M" first="Mark J" last="Daly">Mark J. Daly</name><name sortKey="Floratos, Aris" sort="Floratos, Aris" uniqKey="Floratos A" first="Aris" last="Floratos">Aris Floratos</name><name sortKey="Fontana, Robert J" sort="Fontana, Robert J" uniqKey="Fontana R" first="Robert J" last="Fontana">Robert J. Fontana</name><name sortKey="Hayashi, Paul H" sort="Hayashi, Paul H" uniqKey="Hayashi P" first="Paul H" last="Hayashi">Paul H. Hayashi</name><name sortKey="Nelson, Matthew R" sort="Nelson, Matthew R" uniqKey="Nelson M" first="Matthew R" last="Nelson">Matthew R. Nelson</name><name sortKey="Sawle, Ashley" sort="Sawle, Ashley" uniqKey="Sawle A" first="Ashley" last="Sawle">Ashley Sawle</name><name sortKey="Serrano, Jose" sort="Serrano, Jose" uniqKey="Serrano J" first="Jose" last="Serrano">Jose Serrano</name><name sortKey="Shen, Yufeng" sort="Shen, Yufeng" uniqKey="Shen Y" first="Yufeng" last="Shen">Yufeng Shen</name><name sortKey="Stolz, Andrew" sort="Stolz, Andrew" uniqKey="Stolz A" first="Andrew" last="Stolz">Andrew Stolz</name><name sortKey="Urban, Thomas J" sort="Urban, Thomas J" uniqKey="Urban T" first="Thomas J" last="Urban">Thomas J. Urban</name><name sortKey="Watkins, Paul B" sort="Watkins, Paul B" uniqKey="Watkins P" first="Paul B" last="Watkins">Paul B. Watkins</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Aithal, Guruprasad P" sort="Aithal, Guruprasad P" uniqKey="Aithal G" first="Guruprasad P" last="Aithal">Guruprasad P. Aithal</name></noRegion><name sortKey="Coulthard, Sally A" sort="Coulthard, Sally A" uniqKey="Coulthard S" first="Sally A" last="Coulthard">Sally A. Coulthard</name><name sortKey="Daly, Ann K" sort="Daly, Ann K" uniqKey="Daly A" first="Ann K" last="Daly">Ann K. Daly</name><name sortKey="Day, Christopher P" sort="Day, Christopher P" uniqKey="Day C" first="Christopher P" last="Day">Christopher P. Day</name><name sortKey="Dillon, John F" sort="Dillon, John F" uniqKey="Dillon J" first="John F" last="Dillon">John F. Dillon</name><name sortKey="Grove, Jane I" sort="Grove, Jane I" uniqKey="Grove J" first="Jane I" last="Grove">Jane I. Grove</name><name sortKey="Molokhia, Mariam" sort="Molokhia, Mariam" uniqKey="Molokhia M" first="Mariam" last="Molokhia">Mariam Molokhia</name><name sortKey="Pirmohamed, Munir" sort="Pirmohamed, Munir" uniqKey="Pirmohamed M" first="Munir" last="Pirmohamed">Munir Pirmohamed</name></country><country name="Islande"><noRegion><name sortKey="Bjornsson, Einar S" sort="Bjornsson, Einar S" uniqKey="Bjornsson E" first="Einar S" last="Bjornsson">Einar S. Bjornsson</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Andrade, Raul J" sort="Andrade, Raul J" uniqKey="Andrade R" first="Raul J" last="Andrade">Raul J. Andrade</name></noRegion><name sortKey="Carvajal, Alfonso" sort="Carvajal, Alfonso" uniqKey="Carvajal A" first="Alfonso" last="Carvajal">Alfonso Carvajal</name><name sortKey="Iba Ez, Luisa" sort="Iba Ez, Luisa" uniqKey="Iba Ez L" first="Luisa" last="Ibá Ez">Luisa Ibá Ez</name><name sortKey="Lucena, M Isabel" sort="Lucena, M Isabel" uniqKey="Lucena M" first="M Isabel" last="Lucena">M Isabel Lucena</name><name sortKey="Stephens, Camilla" sort="Stephens, Camilla" uniqKey="Stephens C" first="Camilla" last="Stephens">Camilla Stephens</name></country><country name="Chili"><noRegion><name sortKey="Arrese, Marco" sort="Arrese, Marco" uniqKey="Arrese M" first="Marco" last="Arrese">Marco Arrese</name></noRegion></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Bondon Guitton, Emmanuelle" sort="Bondon Guitton, Emmanuelle" uniqKey="Bondon Guitton E" first="Emmanuelle" last="Bondon-Guitton">Emmanuelle Bondon-Guitton</name></region><name sortKey="Larrey, Dominique" sort="Larrey, Dominique" uniqKey="Larrey D" first="Dominique" last="Larrey">Dominique Larrey</name></country><country name="Argentine"><noRegion><name sortKey="Bessone, Fernando" sort="Bessone, Fernando" uniqKey="Bessone F" first="Fernando" last="Bessone">Fernando Bessone</name></noRegion></country><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Cascorbi, Ingolf" sort="Cascorbi, Ingolf" uniqKey="Cascorbi I" first="Ingolf" last="Cascorbi">Ingolf Cascorbi</name></region></country><country name="Italie"><noRegion><name sortKey="Conforti, Anita" sort="Conforti, Anita" uniqKey="Conforti A" first="Anita" last="Conforti">Anita Conforti</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Hallberg, P R" sort="Hallberg, P R" uniqKey="Hallberg P" first="P R" last="Hallberg">P R Hallberg</name></region><name sortKey="Wadelius, Mia" sort="Wadelius, Mia" uniqKey="Wadelius M" first="Mia" last="Wadelius">Mia Wadelius</name></country><country name="Uruguay"><noRegion><name sortKey="Hernandez, Nelia" sort="Hernandez, Nelia" uniqKey="Hernandez N" first="Nelia" last="Hernández">Nelia Hernández</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Kullak Ublick, Gerd A" sort="Kullak Ublick, Gerd A" uniqKey="Kullak Ublick G" first="Gerd A" last="Kullak-Ublick">Gerd A. Kullak-Ublick</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Laitinen, Tarja" sort="Laitinen, Tarja" uniqKey="Laitinen T" first="Tarja" last="Laitinen">Tarja Laitinen</name></noRegion></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Maitland Van Der Zee, Anke H" sort="Maitland Van Der Zee, Anke H" uniqKey="Maitland Van Der Zee A" first="Anke H" last="Maitland-Van Der Zee">Anke H. Maitland-Van Der Zee</name></region></country><country name="Australie"><noRegion><name sortKey="Martin, Jennifer H" sort="Martin, Jennifer H" uniqKey="Martin J" first="Jennifer H" last="Martin">Jennifer H. Martin</name></noRegion><name sortKey="Powell, Elizabeth E" sort="Powell, Elizabeth E" uniqKey="Powell E" first="Elizabeth E" last="Powell">Elizabeth E. Powell</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Qin, Shengying" sort="Qin, Shengying" uniqKey="Qin S" first="Shengying" last="Qin">Shengying Qin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28043905" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |